Danuta S Kalinowski Selected Research

Thiosemicarbazones

10/2019	Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes.
4/2019	Novel SPME fibers based on a plastic support for determination of plasma protein binding of thiosemicarbazone metal chelators: a case example of DpC, an anti-cancer drug that entered clinical trials.
1/2019	Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents.
10/2017	A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.
1/2017	Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).
9/2016	The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.
9/2016	Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance.
1/2016	The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.
1/2016	Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity.
1/2016	Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

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Danuta S Kalinowski Research Topics

Disease

53	Neoplasms (Cancer) 10/2020 - 12/2005
13	Neoplasm Metastasis (Metastasis) 01/2017 - 01/2013
5	Iron Overload 01/2013 - 12/2005
3	Adenocarcinoma 01/2015 - 10/2012
2	Friedreich Ataxia (Friedreich's Ataxia) 01/2020 - 01/2016
2	Hypoxia (Hypoxemia) 10/2019 - 07/2012
2	Alzheimer Disease (Alzheimer's Disease) 05/2018 - 10/2017
2	Carcinoma (Carcinomatosis) 01/2015 - 01/2013
2	Leukemia 01/2015 - 03/2009
2	Cardiotoxicity 08/2012 - 01/2009
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2020
1	Cardiomyopathies (Cardiomyopathy) 01/2020
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2019
1	Inflammation (Inflammations) 01/2017
1	Neuroblastoma 09/2016
1	Ataxia (Dyssynergia) 01/2016
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2015
1	Prostatic Neoplasms (Prostate Cancer) 01/2015
1	Adenocarcinoma of Lung 01/2015
1	Infections 02/2014
1	Breast Neoplasms (Breast Cancer) 01/2014

Drug/Important Bio-Agent (IBA)

31	Chelating AgentsIBA 04/2019 - 12/2005
29	ThiosemicarbazonesIBA 10/2019 - 01/2009
27	IronIBA 10/2020 - 12/2005
13	di- 2- pyridylketone- 4,4- dimethyl- 3- thiosemicarbazoneIBA 09/2016 - 01/2009
11	CopperIBA 10/2019 - 12/2006
9	LigandsIBA 08/2015 - 01/2008
8	MetalsIBA 04/2019 - 03/2013
7	Deferoxamine (Desferal)FDA LinkGeneric 01/2015 - 12/2006
6	Pharmaceutical PreparationsIBA 04/2019 - 10/2010
5	di-2-pyridylketone 4- cyclohexyl- 4- methyl- 3- thiosemicarbazoneIBA 04/2019 - 01/2015
5	Antineoplastic Agents (Antineoplastics)IBA 01/2019 - 12/2006
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 03/2013
4	HydrazonesIBA 05/2018 - 01/2008
4	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2016 - 01/2014
4	2-benzoylpyridineIBA 02/2013 - 01/2011
2	FrataxinIBA 01/2020 - 01/2016
2	Glyoxal (Ethanedial)IBA 10/2019 - 11/2015
2	Phosphotransferases (Kinase)IBA 01/2019 - 11/2015
2	tyrosine receptor (receptor, tyrosine)IBA 01/2019 - 11/2015
2	AntioxidantsIBA 01/2019 - 11/2015
2	SemicarbazonesIBA 05/2018 - 01/2015
2	AdamantaneIBA 05/2018 - 02/2010
2	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2016 - 10/2015
2	Ferritins (Ferritin)IBA 01/2016 - 03/2013
2	LipidsIBA 01/2016 - 01/2014
2	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 10/2015 - 04/2014
2	DNA (Deoxyribonucleic Acid)IBA 10/2015 - 04/2014
2	3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA 04/2014 - 12/2006
2	SiderophoresIBA 01/2014 - 01/2011
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2014 - 01/2014
2	Biological ProductsIBA 01/2014 - 06/2012
2	Caspase 3 (Caspase-3)IBA 01/2013 - 03/2009
2	2-benzoylpyridine 4-ethyl-3-thiosemicarbazoneIBA 10/2012 - 10/2010
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2020
1	Diacetyl (Biacetyl)IBA 10/2019
1	Blood Proteins (Serum Proteins)IBA 04/2019
1	PlasticsIBA 04/2019
1	4-sulfophenylmethallyl ether (SPME)IBA 04/2019
1	Amyloid (Amyloid Fibrils)IBA 05/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017
1	CaspasesIBA 09/2016
1	Annexin A5IBA 09/2016
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 09/2016
1	3- beta- (2- (diethylamino)ethoxy)androst- 5- en- 17- oneIBA 07/2016
1	CholesterolIBA 07/2016
1	human ERBB2 proteinIBA 01/2016
1	ErbB Receptors (EGF Receptor)IBA 01/2016
1	Transferrin (beta 2 Transferrin)IBA 01/2016
1	Liposomes (Liposome)IBA 01/2016
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2016
1	IntegrinsIBA 11/2015
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2015
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 11/2015
1	Acetylcysteine (Siran)FDA LinkGeneric 11/2015
1	glyoxal- bis(4- methylthiosemicarbazonato)copper(II)IBA 11/2015
1	tetrathiomolybdate (ammonium tetrathiomolybdate)IBA 11/2015
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2015
1	Cyclin D1IBA 10/2015
1	Human Serum Albumin FDA LinkGeneric 04/2015
1	InterleukinsIBA 01/2015
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2015
1	EnzymesIBA 04/2014
1	Iron Chelating AgentsIBA 02/2014
1	PiperazineIBA 01/2014
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2014
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2014
1	Drug CarriersIBA 01/2014
1	BromineIBA 01/2014
1	Fluorouracil (Carac)FDA LinkGeneric 01/2014
1	AlbuminsIBA 01/2014
1	Methotrexate (Mexate)FDA LinkGeneric 01/2014
1	NitrogenIBA 01/2014
1	Estrogen ReceptorsIBA 01/2014
1	SulfurIBA 01/2014
1	Tamoxifen FDA LinkGeneric 01/2014
1	salicylaldehyde isonicotinoyl hydrazoneIBA 01/2014

Therapy/Procedure

11	Therapeutics 01/2019 - 12/2006
3	Drug Therapy (Chemotherapy) 01/2014 - 05/2007
1	Aftercare (After-Treatment) 01/2014